Roles for mycobacterial DinB2 in frameshift and substitution mutagenesis

Roles for mycobacterial DinB2 in frameshift and substitution mutagenesis

Translesion synthesis by translesion polymerases is a conserved mechanism of DNA damage tolerance. In bacteria, DinB enzymes are the widely distributed promutagenic translesion polymerases. The role of DinBs in mycobacterial mutagenesis was unclear until recent studies revealed a role for mycobacter...

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Bibliographic Details
Main Authors: Pierre Dupuy, Shreya Ghosh, Allison Fay, Oyindamola Adefisayo, Richa Gupta, Stewart Shuman, Michael S Glickman
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2023-05-01
Series:eLife
Subjects:
Mycobacterium smegmatis
Mycobacterium tuberculoiss
mutagenesis
DNA damage response
antimicrobial resistance
Online Access:https://elifesciences.org/articles/83094

Internet

https://elifesciences.org/articles/83094

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