Aging impairs the osteocytic regulation of collagen integrity and bone quality

Aging impairs the osteocytic regulation of collagen integrity and bone quality

Abstract Poor bone quality is a major factor in skeletal fragility in elderly individuals. The molecular mechanisms that establish and maintain bone quality, independent of bone mass, are unknown but are thought to be primarily determined by osteocytes. We hypothesize that the age-related decline in...

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Main Authors: Charles A. Schurman, Serra Kaya, Neha Dole, Nadja M. Maldonado Luna, Natalia Castillo, Ryan Potter, Jacob P. Rose, Joanna Bons, Christina D. King, Jordan B. Burton, Birgit Schilling, Simon Melov, Simon Tang, Eric Schaible, Tamara Alliston
Format: Article
Language:English
Published: Nature Publishing Group 2024-02-01
Series:Bone Research
Online Access:https://doi.org/10.1038/s41413-023-00303-7

Internet

https://doi.org/10.1038/s41413-023-00303-7

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