Napabucasin-loaded PLGA nanoparticles trigger anti-HCC immune responses by metabolic reprogramming of tumor-associated macrophages

Napabucasin-loaded PLGA nanoparticles trigger anti-HCC immune responses by metabolic reprogramming of tumor-associated macrophages

Abstract Background JAK/STAT3 is one of the critical signaling pathways involved in the occurrence and development of hepatocellular carcinoma (HCC). BBI608 (Napabucasin), as a novel small molecule inhibitor of STAT3, has shown previously excellent anti-HCC effects in vitro and in mouse models. Howe...

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Bibliographic Details
Main Authors: Zhenwei Song, Hongfei Chen, Xueyao Wang, Zhiyue Zhang, Hui Li, Huajun Zhao, Yang Liu, Qiuju Han, Jian Zhang
Format: Article
Language:English
Published: BMC 2024-12-01
Series:Journal of Translational Medicine
Subjects:
STAT3
Napabucasin
Nanoparticles
TAMs
FAO
Online Access:https://doi.org/10.1186/s12967-024-05917-x

Internet

https://doi.org/10.1186/s12967-024-05917-x

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