Enhanced neutralization potency of an identical HIV neutralizing antibody expressed as different isotypes is achieved through genetically distinct mechanisms

Enhanced neutralization potency of an identical HIV neutralizing antibody expressed as different isotypes is achieved through genetically distinct mechanisms

Abstract Antibodies with the same variable region can exist as multiple isotypes with varying neutralization potencies, though the mechanism for this is not fully defined. We previously isolated an HIV-directed IgA1 monoclonal antibody (mAb), CAP88-CH06, and showed that IgA1 and IgG3 isotypes of thi...

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Bibliographic Details
Main Authors: Thandeka Moyo-Gwete, Cathrine Scheepers, Zanele Makhado, Prudence Kgagudi, Nonkululeko B. Mzindle, Rutendo Ziki, Sharon Madzorera, Nelia P. Manamela, Frances Ayres, Bronwen E. Lambson, Simone I. Richardson, Lynn Morris, Penny L. Moore
Format: Article
Language:English
Published: Nature Portfolio 2022-10-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-022-20141-7

Internet

https://doi.org/10.1038/s41598-022-20141-7

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