Analytical sensitivity of a method is critical in detection of low-level BRCA1 constitutional epimutation

Analytical sensitivity of a method is critical in detection of low-level BRCA1 constitutional epimutation

Abstract Recent reports based on a substantial number of cases, warrant need for population-based research to determine implications of constitutional methylation of tumor suppressor genes such as BRCA1 occurring in healthy tissue in the prediction of cancer. However, the detection of the constituti...

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Bibliographic Details
Main Authors: Filip Machaj, Katarzyna Ewa Sokolowska, Konrad Borowski, Szymon Retfiński, Dominik Strapagiel, Marta Sobalska-Kwapis, Tomasz Huzarski, Jan Lubiński, Tomasz Kazimierz Wojdacz
Format: Article
Language:English
Published: Nature Portfolio 2023-09-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-023-43276-7

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https://doi.org/10.1038/s41598-023-43276-7

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