General Synthesis of 1-Aryl-6-azaisocytosines and Their Utilization for the Preparation of Related Condensed 1,2,4-Triazines

General Synthesis of 1-Aryl-6-azaisocytosines and Their Utilization for the Preparation of Related Condensed 1,2,4-Triazines

A simple general synthesis of 1-aryl-6-azaisocytosine-5-carbonitriles <b>4</b> is described. This method is based on coupling diazonium salts with cyanoacetylcyanamide <b>2</b> and then cyclization of the formed 2-arylhydrazono-2-cyanoacetylcyanamides <b>3</b>. Th...

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Bibliographic Details
Main Authors: František Zálešák, Jan Slouka, Jakub Stýskala
Format: Article
Language:English
Published: MDPI AG 2019-10-01
Series:Molecules
Subjects:
1-aryl-6-azaisocytosine
1,2,4-triazine
condensed 1,2,4-triazine
fused azaisocytosines
cyclization of arylhydrazones
Online Access:https://www.mdpi.com/1420-3049/24/19/3558

Internet

https://www.mdpi.com/1420-3049/24/19/3558

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