Effect of the Ketoprofen Distribution in Cream-gels on the Formation of the Impurities

Introduction. The fixed combination of ketoprofen, methyl salicylate and levomenthol in the form of a cream-gel is rational. Ketoprofen forms salts with bases and esters with substances containing hydroxyl groups. Ketoprofen is practically insoluble in water, and the solubility of ketoprofen salts i...

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Bibliographic Details
Main Authors: N. A. Lyapunov, I. A. Zinchenko, E. P. Bezuglaya, A. A. Lysokobilka
Format: Article
Language:Russian
Published: LLC Center of Pharmaceutical Analytics (LLC «CPHA») 2019-05-01
Series:Разработка и регистрация лекарственных средств
Subjects:
Online Access:https://www.pharmjournal.ru/jour/article/view/682