Selective vulnerability of human-induced pluripotent stem cells to dihydroorotate dehydrogenase inhibition during mesenchymal stem/stromal cell purification

Selective vulnerability of human-induced pluripotent stem cells to dihydroorotate dehydrogenase inhibition during mesenchymal stem/stromal cell purification

The use of induced mesenchymal stem/stromal cells (iMSCs) derived from human induced pluripotent stem cells (hiPSCs) in regenerative medicine involves the risk of teratoma formation due to hiPSCs contamination in iMSCs. Therefore, eradicating the remaining undifferentiated hiPSCs is crucial for the...

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Bibliographic Details
Main Authors: Ziadoon Al-Akashi, Denise Zujur, Daisuke Kamiya, Tomohisa Kato, Toru Kondo, Makoto Ikeya
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-02-01
Series:Frontiers in Cell and Developmental Biology
Subjects:
mesenchymal stem/stromal cells (MSCs)
induced mesenchymal stromal cells (iMSCs)
induced pluripotent stem cells (hiPSC)
pyrimidine biosynthesis
dihydroorotate dehydrogenase (DHODH)
brequinar (BRQ)
Online Access:https://www.frontiersin.org/articles/10.3389/fcell.2023.1089945/full

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https://www.frontiersin.org/articles/10.3389/fcell.2023.1089945/full

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