Baicalin protects the cardiomyocytes from ER stress-induced apoptosis: inhibition of CHOP through induction of endothelial nitric oxide synthase.

Baicalin protects the cardiomyocytes from ER stress-induced apoptosis: inhibition of CHOP through induction of endothelial nitric oxide synthase.

Baicalin, the main active ingredient of the Scutellaria root, exerts anti-oxidant and anti-apoptotic effects in cardiovascular diseases. However, the therapeutic mechanism of baicalin remains unknown. Cultured neonatal rat cardiomyocytes were pre-treated with baicalin (0-50 µM) for 24 h, and subsequ...

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Main Authors: Mingzhi Shen, Lin Wang, Guodong Yang, Lei Gao, Bo Wang, Xiaowang Guo, Chao Zeng, Yong Xu, Liangliang Shen, Ke Cheng, Yuesheng Xia, Xiumin Li, Haichang Wang, Li Fan, Xiaoming Wang
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2014-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3919764?pdf=render

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http://europepmc.org/articles/PMC3919764?pdf=render

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