Amplification of poly(I:C)-induced interleukin-6 production in human bronchial epithelial cells by priming with interferon-γ

Abstract Proinflammatory cytokine interleukin (IL)-6 was associated with disease severity in patients with COVID-19. The mechanism underlying the excessive IL-6 production by SARS-Cov-2 infection remains unclear. Respiratory viruses initially infect nasal or bronchial epithelial cells that produce v...

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Bibliographic Details
Main Authors: Norikazu Okuma, Masa-aki Ito, Tomoyoshi Shimizu, Atsuya Hasegawa, Shin’ya Ohmori, Kazuki Yoshida, Isao Matsuoka
Format: Article
Language:English
Published: Nature Portfolio 2023-11-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-023-48422-9