3-(Adenosylthio)benzoic Acid Derivatives as SARS-CoV-2 Nsp14 Methyltransferase Inhibitors

3-(Adenosylthio)benzoic Acid Derivatives as SARS-CoV-2 Nsp14 Methyltransferase Inhibitors

SARS-CoV-2 nsp14 guanine-<i>N</i>7-methyltransferase plays an important role in the viral RNA translation process by catalyzing the transfer of a methyl group from <i>S</i>-adenosyl-methionine (SAM) to viral mRNA cap. We report a structure-guided design and synthesis of 3-(ad...

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Bibliographic Details
Main Authors: Olga Bobileva, Raitis Bobrovs, Evelina Elva Sirma, Iveta Kanepe, Anna L. Bula, Liene Patetko, Anna Ramata-Stunda, Solveiga Grinberga, Aigars Jirgensons, Kristaps Jaudzems
Format: Article
Language:English
Published: MDPI AG 2023-01-01
Series:Molecules
Subjects:
SARS-CoV-2
nsp14
nsp16
methyltransferase inhibitors
Online Access:https://www.mdpi.com/1420-3049/28/2/768

Internet

https://www.mdpi.com/1420-3049/28/2/768

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