Filamin C Deficiency Impairs Sarcomere Stability and Activates Focal Adhesion Kinase through PDGFRA Signaling in Induced Pluripotent Stem Cell-Derived Cardiomyocytes

Filamin C Deficiency Impairs Sarcomere Stability and Activates Focal Adhesion Kinase through PDGFRA Signaling in Induced Pluripotent Stem Cell-Derived Cardiomyocytes

Truncating mutations in filamin C (<i>FLNC</i>) are associated with dilated cardiomyopathy and arrhythmogenic cardiomyopathy. FLNC is an actin-binding protein and is known to interact with transmembrane and structural proteins; hence, the ablation of FLNC in cardiomyocytes is expected to...

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Bibliographic Details
Main Authors: Shanshan Gao, Lingaonan He, Chi Keung Lam, Matthew R. G. Taylor, Luisa Mestroni, Raffaella Lombardi, Suet Nee Chen
Format: Article
Language:English
Published: MDPI AG 2024-02-01
Series:Cells
Subjects:
filamin C
dilated cardiomyopathy
PDGFRA
crenolanib
Online Access:https://www.mdpi.com/2073-4409/13/3/278

Internet

https://www.mdpi.com/2073-4409/13/3/278

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