Modeling pharmacodynamic response to the poly(ADP-Ribose) polymerase inhibitor ABT-888 in human peripheral blood mononuclear cells.

Modeling pharmacodynamic response to the poly(ADP-Ribose) polymerase inhibitor ABT-888 in human peripheral blood mononuclear cells.

Poly(ADP-ribose) polymerase (PARP) facilitates DNA repair and PARP inhibitors may potentiate the effect of DNA-damaging chemotherapeutic agents in patients with cancer. Collection of peripheral blood mononuclear cells (PBMCs) as a surrogate tissue to monitor PARP inhibitor pharmacodynamic effects ha...

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Bibliographic Details
Main Authors: Jiuping Ji, Robert J Kinders, Yiping Zhang, Larry Rubinstein, Shivaani Kummar, Ralph E Parchment, Joseph E Tomaszewski, James H Doroshow
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2011-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3189959?pdf=render

Internet

http://europepmc.org/articles/PMC3189959?pdf=render

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