Helicase-like transcription factor (Hltf)-deletion activates Hmgb1-Rage axis and granzyme A-mediated killing of pancreatic β cells resulting in neonatal lethality.

Helicase-like transcription factor (Hltf)-deletion activates Hmgb1-Rage axis and granzyme A-mediated killing of pancreatic β cells resulting in neonatal lethality.

Epigenetic mechanisms are integral to pancreatic β cell function. Promoter hypermethylation of the helicase like-transcription factor (HLTF) gene-a component of the cellular DNA damage response that contributes to genome stability-has been implicated in age-associated changes in β cells. To study HL...

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Bibliographic Details
Main Authors: Gurvinder Kaur, Rebecca A Helmer, Dalia Martinez-Marin, Souad R Sennoune, Rachel L Washburn, Raul Martinez-Zaguilan, Jannette M Dufour, Beverly S Chilton
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2023-01-01
Series:PLoS ONE
Online Access:https://doi.org/10.1371/journal.pone.0286109

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https://doi.org/10.1371/journal.pone.0286109

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