Targeting histone deacetylase SIRT1 selectively eradicates EGFR TKI-resistant cancer stem cells via regulation of mitochondrial oxidative phosphorylation in lung adenocarcinoma

Targeting histone deacetylase SIRT1 selectively eradicates EGFR TKI-resistant cancer stem cells via regulation of mitochondrial oxidative phosphorylation in lung adenocarcinoma

Lung adenocarcinoma (LAD) is a human malignancy successfully treated with the tyrosine kinase inhibitor (TKI) gefitinib; however, the enrichment of therapy resistant cancer stem cells (CSCs) in such patients is assumed to be a source of treatment failure. Evaluation of LAD cell populations treated w...

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Bibliographic Details
Main Authors: Jiangtao Sun, Guifang Li, Yiwen Liu, Mingyang Ma, Kaifang Song, Huaxu Li, Daxing Zhu, XiaoJun Tang, Jinyu Kong, Xiang Yuan
Format: Article
Language:English
Published: Elsevier 2020-01-01
Series:Neoplasia: An International Journal for Oncology Research
Online Access:http://www.sciencedirect.com/science/article/pii/S1476558619303963

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http://www.sciencedirect.com/science/article/pii/S1476558619303963

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