Neddylation: a novel modulator of the tumor microenvironment

Neddylation: a novel modulator of the tumor microenvironment

Abstract Neddylation, a post-translational modification that adds an ubiquitin-like protein NEDD8 to substrate proteins, modulates many important biological processes, including tumorigenesis. The process of protein neddylation is overactivated in multiple human cancers, providing a sound rationale...

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Bibliographic Details
Main Authors: Lisha Zhou, Yanyu Jiang, Qin Luo, Lihui Li, Lijun Jia
Format: Article
Language:English
Published: BMC 2019-04-01
Series:Molecular Cancer
Subjects:
Neddylation
Tumor microenvironment
Tumor-derived factors
Cancer-associated fibroblasts
Cancer-associated endothelial cells
Immune cells
Online Access:http://link.springer.com/article/10.1186/s12943-019-0979-1

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http://link.springer.com/article/10.1186/s12943-019-0979-1

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