Factor B and C4b2a Autoantibodies in C3 Glomerulopathy

C3 Glomerulopathy (C3G) is a renal disease mediated primarily by dysregulation of the alternative pathway of complement. Complement is the cornerstone of innate immunity. It targets infectious microbes for destruction, clears immune complexes, and apoptotic cells from the circulation, and augments t...

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Bibliographic Details
Main Authors: Jill J. Hauer, Dingwu Shao, Yuzhou Zhang, Carla M. Nester, Richard J. H. Smith
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-04-01
Series:Frontiers in Immunology
Subjects:
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2019.00668/full