Inactivation of AUF1 in Myeloid Cells Protects From Allergic Airway and Tumor Infiltration and Impairs the Adenosine-Induced Polarization of Pro-Angiogenic Macrophages

Inactivation of AUF1 in Myeloid Cells Protects From Allergic Airway and Tumor Infiltration and Impairs the Adenosine-Induced Polarization of Pro-Angiogenic Macrophages

The four isoforms of the RNA-binding protein hnRNPD/AUF1 have been proposed to limit the use of inflammatory mRNAs in innate immune cells. Mice engineered to lack AUF1s in all tissues are sensitive to acute inflammatory assaults; however, they also manifest complex degenerations obscuring assessment...

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Bibliographic Details
Main Authors: Sofia Gargani, Niki Lourou, Christina Arapatzi, Dimitris Tzanos, Marania Saridaki, Esmeralda Dushku, Margarita Chatzimike, Nikolaos D. Sidiropoulos, Margarita Andreadou, Vasileios Ntafis, Pantelis Hatzis, Vassiliki Kostourou, Dimitris L. Kontoyiannis
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-02-01
Series:Frontiers in Immunology
Subjects:
inflammation
innate immunity
post-transcriptional regulation
RNA-binding proteins
animal models
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2022.752215/full

Internet

https://www.frontiersin.org/articles/10.3389/fimmu.2022.752215/full

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