Mitochondrial calcium uniporter stabilization preserves energetic homeostasis during Complex I impairment

Mitochondrial calcium uniporter stabilization preserves energetic homeostasis during Complex I impairment

Mitochondrial complex I deficiency is frequent in congenital, neurologic and cardiovascular disease. Here the authors demonstrate that Complex I stimulates the turnover of a mitochondrial calcium channel, which becomes stabilized during Complex I deficiency, preserving energetic homeostasis.

Dades bibliogràfiques
Autors principals: Enrique Balderas, David R. Eberhardt, Sandra Lee, John M. Pleinis, Salah Sommakia, Anthony M. Balynas, Xue Yin, Mitchell C. Parker, Colin T. Maguire, Scott Cho, Marta W. Szulik, Anna Bakhtina, Ryan D. Bia, Marisa W. Friederich, Timothy M. Locke, Johan L. K. Van Hove, Stavros G. Drakos, Yasemin Sancak, Martin Tristani-Firouzi, Sarah Franklin, Aylin R. Rodan, Dipayan Chaudhuri
Format: Article
Idioma:English
Publicat: Nature Portfolio 2022-05-01
Col·lecció:Nature Communications
Accés en línia:https://doi.org/10.1038/s41467-022-30236-4

Internet

https://doi.org/10.1038/s41467-022-30236-4

Ítems similars