Hemocyte differentiation to the megacyte lineage enhances mosquito immunity against Plasmodium

Hemocyte differentiation to the megacyte lineage enhances mosquito immunity against Plasmodium

Activation of Toll signaling in Anopheles gambiae by silencing Cactus, a suppressor of this pathway, enhances local release of hemocyte-derived microvesicles (HdMv), promoting activation of the mosquito complement-like system, which eliminates Plasmodium ookinetes. We uncovered the mechanism of this...

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Bibliographic Details
Main Authors: Ana Beatriz F Barletta, Banhisikha Saha, Nathanie Trisnadi, Octavio AC Talyuli, Gianmarco Raddi, Carolina Barillas-Mury
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2022-09-01
Series:eLife
Subjects:
Anopheles gambiae
mosquito
megacyte
Toll pathway
antiplasmodial immunity
hemocytes
Online Access:https://elifesciences.org/articles/81116

Internet

https://elifesciences.org/articles/81116

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