Test-statistic inflation in methylome-wide association studies

Test-statistic inflation in methylome-wide association studies

Recent years have seen a surge of methylome-wide association studies (MWAS). We observed that many of these studies suffer from test statistic inflation that is most likely caused by commonly used quality control (QC) pipelines not going far enough to remove technical artefacts. To support this clai...

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Bibliographic Details
Main Authors: Jerry Guintivano, Andrey A Shabalin, Robin F. Chan, David R. Rubinow, Patrick F. Sullivan, Samantha Meltzer-Brody, Karolina a Aberg, Edwin J. C. G. van den Oord
Format: Article
Language:English
Published: Taylor & Francis Group 2020-11-01
Series:Epigenetics
Subjects:
dna methylation
epigenetics
reproducibility
Online Access:http://dx.doi.org/10.1080/15592294.2020.1758382

Internet

http://dx.doi.org/10.1080/15592294.2020.1758382

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