Genomic Alterations, Gene Expression Profiles and Functional Enrichment of Normal-Karyotype Acute Myeloid Leukaemia Based on Targeted Next-Generation Sequencing

Genomic Alterations, Gene Expression Profiles and Functional Enrichment of Normal-Karyotype Acute Myeloid Leukaemia Based on Targeted Next-Generation Sequencing

Characterising genomic variants is paramount in understanding the pathogenesis and heterogeneity of normal-karyotype acute myeloid leukaemia (AML-NK). In this study, clinically significant genomic biomarkers were ascertained using targeted DNA sequencing and RNA sequencing on eight AML-NK patients’...

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Bibliographic Details
Main Authors: Angeli Ambayya, Rozaimi Razali, Sarina Sulong, Ezzanie Suffya Zulkefli, Yee Yee Yap, Jameela Sathar, Rosline Hassan
Format: Article
Language:English
Published: MDPI AG 2023-02-01
Series:Cancers
Subjects:
acute myeloid leukaemia
next generation sequencing
gene expression
somatic variants
functional enrichment
Online Access:https://www.mdpi.com/2072-6694/15/5/1386

Internet

https://www.mdpi.com/2072-6694/15/5/1386

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