Routine multiplex mutational profiling of melanomas enables enrollment in genotype-driven therapeutic trials.

Routine multiplex mutational profiling of melanomas enables enrollment in genotype-driven therapeutic trials.

Knowledge of tumor mutation status is becoming increasingly important for the treatment of cancer, as mutation-specific inhibitors are being developed for clinical use that target only sub-populations of patients with particular tumor genotypes. Melanoma provides a recent example of this paradigm. W...

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Bibliographic Details
Main Authors: Christine M Lovly, Kimberly Brown Dahlman, Laurel E Fohn, Zengliu Su, Dora Dias-Santagata, Donna J Hicks, Donald Hucks, Elizabeth Berry, Charles Terry, MarKeesa Duke, Yingjun Su, Tammy Sobolik-Delmaire, Ann Richmond, Mark C Kelley, Cindy L Vnencak-Jones, A John Iafrate, Jeffrey Sosman, William Pao
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2012-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3335021?pdf=render

Internet

http://europepmc.org/articles/PMC3335021?pdf=render

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