Mechanistic insights gained from cell and molecular analysis of the neuroprotective potential of bioactive natural compounds in an immortalized hippocampal cell line.

Mechanistic insights gained from cell and molecular analysis of the neuroprotective potential of bioactive natural compounds in an immortalized hippocampal cell line.

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Evaluating novel compounds for neuroprotective effects in animal models of traumatic brain injury (TBI) is a protracted, labor-intensive and costly effort. However, the present lack of effective treatment options for TBI, despite decades of research, shows the critical need for alternative methods f...

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Bibliographic Details
Main Authors: Harris A Weisz, Deborah R Boone, William S Coggins, Gabrielle A Edwards, Hannah E Willey, Steven G Widen, Dionicio Siegel, Andrew T Nelson, Donald S Prough, Helen L Hellmich
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2022-01-01
Series:PLoS ONE
Online Access:https://doi.org/10.1371/journal.pone.0267682

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https://doi.org/10.1371/journal.pone.0267682

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