Single cell transcriptomic profiling of a neuron-astrocyte assembloid tauopathy model

Single cell transcriptomic profiling of a neuron-astrocyte assembloid tauopathy model

Single cell RNA-sequencing of the AstTau neuron-asteroid tau assembloid model reveals excitatory neuron inflammatory signatures and an astrocytic heat shock response similar to that occurring in the brains of individuals with tauopathies, which can be ameliorated with a neuroprotective HSP90 inhibit...

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Bibliographic Details
Main Authors: Hannah Drew Rickner, Lulu Jiang, Rui Hong, Nicholas K. O’Neill, Chromewell A. Mojica, Benjamin J. Snyder, Lushuang Zhang, Dipan Shaw, Maria Medalla, Benjamin Wolozin, Christine S. Cheng
Format: Article
Language:English
Published: Nature Portfolio 2022-10-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-022-34005-1

Internet

https://doi.org/10.1038/s41467-022-34005-1

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