Single cell transcriptomic profiling of a neuron-astrocyte assembloid tauopathy model
Single cell RNA-sequencing of the AstTau neuron-asteroid tau assembloid model reveals excitatory neuron inflammatory signatures and an astrocytic heat shock response similar to that occurring in the brains of individuals with tauopathies, which can be ameliorated with a neuroprotective HSP90 inhibit...
| Main Authors: | , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2022-10-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-022-34005-1 |
| _version_ | 1811249893968183296 |
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| author | Hannah Drew Rickner Lulu Jiang Rui Hong Nicholas K. O’Neill Chromewell A. Mojica Benjamin J. Snyder Lushuang Zhang Dipan Shaw Maria Medalla Benjamin Wolozin Christine S. Cheng |
| author_facet | Hannah Drew Rickner Lulu Jiang Rui Hong Nicholas K. O’Neill Chromewell A. Mojica Benjamin J. Snyder Lushuang Zhang Dipan Shaw Maria Medalla Benjamin Wolozin Christine S. Cheng |
| author_sort | Hannah Drew Rickner |
| collection | DOAJ |
| description | Single cell RNA-sequencing of the AstTau neuron-asteroid tau assembloid model reveals excitatory neuron inflammatory signatures and an astrocytic heat shock response similar to that occurring in the brains of individuals with tauopathies, which can be ameliorated with a neuroprotective HSP90 inhibitor. |
| first_indexed | 2024-04-12T15:55:25Z |
| format | Article |
| id | doaj.art-c2f626bbe8c54805b65ee8e67aecb7a3 |
| institution | Directory Open Access Journal |
| issn | 2041-1723 |
| language | English |
| last_indexed | 2024-04-12T15:55:25Z |
| publishDate | 2022-10-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj.art-c2f626bbe8c54805b65ee8e67aecb7a32022-12-22T03:26:24ZengNature PortfolioNature Communications2041-17232022-10-0113112210.1038/s41467-022-34005-1Single cell transcriptomic profiling of a neuron-astrocyte assembloid tauopathy modelHannah Drew Rickner0Lulu Jiang1Rui Hong2Nicholas K. O’Neill3Chromewell A. Mojica4Benjamin J. Snyder5Lushuang Zhang6Dipan Shaw7Maria Medalla8Benjamin Wolozin9Christine S. Cheng10Department of Biology, Boston UniversityDepartment of Pharmacology and Experimental Therapeutics, Boston University School of MedicineProgram in Bioinformatics, Boston UniversityProgram in Bioinformatics, Boston UniversityDepartment of Anatomy & Neurobiology, Boston University School of MedicineDepartment of Anatomy & Neurobiology, Boston University School of MedicineDepartment of Pharmacology and Experimental Therapeutics, Boston University School of MedicineInformatics Group, J. Craig Venter InstituteDepartment of Anatomy & Neurobiology, Boston University School of MedicineDepartment of Pharmacology and Experimental Therapeutics, Boston University School of MedicineDepartment of Biology, Boston UniversitySingle cell RNA-sequencing of the AstTau neuron-asteroid tau assembloid model reveals excitatory neuron inflammatory signatures and an astrocytic heat shock response similar to that occurring in the brains of individuals with tauopathies, which can be ameliorated with a neuroprotective HSP90 inhibitor.https://doi.org/10.1038/s41467-022-34005-1 |
| spellingShingle | Hannah Drew Rickner Lulu Jiang Rui Hong Nicholas K. O’Neill Chromewell A. Mojica Benjamin J. Snyder Lushuang Zhang Dipan Shaw Maria Medalla Benjamin Wolozin Christine S. Cheng Single cell transcriptomic profiling of a neuron-astrocyte assembloid tauopathy model Nature Communications |
| title | Single cell transcriptomic profiling of a neuron-astrocyte assembloid tauopathy model |
| title_full | Single cell transcriptomic profiling of a neuron-astrocyte assembloid tauopathy model |
| title_fullStr | Single cell transcriptomic profiling of a neuron-astrocyte assembloid tauopathy model |
| title_full_unstemmed | Single cell transcriptomic profiling of a neuron-astrocyte assembloid tauopathy model |
| title_short | Single cell transcriptomic profiling of a neuron-astrocyte assembloid tauopathy model |
| title_sort | single cell transcriptomic profiling of a neuron astrocyte assembloid tauopathy model |
| url | https://doi.org/10.1038/s41467-022-34005-1 |
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