MESP2 binds competitively to TCF4 to suppress gastric cancer progression by regulating the SKP2/p27 axis

Abstract Gastric cancer (GC) is a major cause of human deaths worldwide, and is notorious for its high incidence and mortality rates. Mesoderm Posterior Basic Helix-loop-helix (bHLH) transcription factor 2 (MESP2) acts as a transcription factor with a conserved bHLH domain. However, whether MESP2 co...

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Bibliographic Details
Main Authors: Lingjun Ge, Gaichao Zhao, Chao Lan, Houji Song, Dan Qi, Pan Huang, Xiaoxue Ke, Hongjuan Cui
Format: Article
Language:English
Published: Nature Publishing Group 2023-03-01
Series:Cell Death Discovery
Online Access:https://doi.org/10.1038/s41420-023-01367-4