Hypoxia Can Induce Migration of Glioblastoma Cells Through a Methylation-Dependent Control of ODZ1 Gene Expression

Hypoxia Can Induce Migration of Glioblastoma Cells Through a Methylation-Dependent Control of ODZ1 Gene Expression

The transmembrane protein ODZ1 has been associated with the invasive capacity of glioblastoma (GBM) cells through upregulation of RhoA/ROCK signaling, but the mechanisms triggering the ODZ1 pathway remain elusive. In addition, it is widely accepted that hypoxia is one of the main biological hallmark...

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Bibliographic Details
Main Authors: Carlos Velásquez, Sheila Mansouri, Olga Gutiérrez, Yasin Mamatjan, Pilar Mollinedo, Shirin Karimi, Olivia Singh, Nuria Terán, Juan Martino, Gelareh Zadeh, José L. Fernández-Luna
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-10-01
Series:Frontiers in Oncology
Subjects:
glioblastoma
methylation
ODZ1
migration
hypoxia
teneurin
Online Access:https://www.frontiersin.org/article/10.3389/fonc.2019.01036/full

Internet

https://www.frontiersin.org/article/10.3389/fonc.2019.01036/full

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