371 Fractalkine isoforms using gene therapy differentially regulate microglia activation and vascular damage in the diabetic retina

371 Fractalkine isoforms using gene therapy differentially regulate microglia activation and vascular damage in the diabetic retina

OBJECTIVES/GOALS: Retinal inflammation caused by the activation of resident macrophages (microglia) during diabetes exacerbates glial cell dysfunction, resulting in neuronal loss. The goal is to use rAAV gene therapy to deliver neuronal-derived fractalkine (FKN), minimizing inflammation and vascular...

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Bibliographic Details
Main Authors: Derek Rodriguez, Kaira A. Church, Alicia N. Pietramale, Sandra M. Cardona, Difernando Vanegas, Isabel A. Muzzio, Kevin R. Nash, Astrid E. Cardona
Format: Article
Language:English
Published: Cambridge University Press 2023-04-01
Series:Journal of Clinical and Translational Science
Online Access:https://www.cambridge.org/core/product/identifier/S2059866123004090/type/journal_article

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https://www.cambridge.org/core/product/identifier/S2059866123004090/type/journal_article

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