Polyamine Metabolism as a Therapeutic Target in Hedgehog-Driven Basal Cell Carcinoma and Medulloblastoma

Polyamine Metabolism as a Therapeutic Target in Hedgehog-Driven Basal Cell Carcinoma and Medulloblastoma

Hedgehog (Hh) signaling is a critical developmental regulator and its aberrant activation, due to somatic or germline mutations of genes encoding pathway components, causes Basal Cell Carcinoma (BCC) and medulloblastoma (MB). A growing effort has been devoted at the identification of druggable vulne...

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Bibliographic Details
Main Authors: Sonia Coni, Laura Di Magno, Silvia Maria Serrao, Yuta Kanamori, Enzo Agostinelli, Gianluca Canettieri
Format: Article
Language:English
Published: MDPI AG 2019-02-01
Series:Cells
Subjects:
Hedgehog
polyamines
medulloblastoma
basal cell carcinoma
<span style="font-variant: small-caps">d</span>,<span style="font-variant: small-caps">l</span>-alpha-difluoromethylornithine
Online Access:https://www.mdpi.com/2073-4409/8/2/150

Internet

https://www.mdpi.com/2073-4409/8/2/150

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