Polyamine Metabolism as a Therapeutic Target in Hedgehog-Driven Basal Cell Carcinoma and Medulloblastoma
Hedgehog (Hh) signaling is a critical developmental regulator and its aberrant activation, due to somatic or germline mutations of genes encoding pathway components, causes Basal Cell Carcinoma (BCC) and medulloblastoma (MB). A growing effort has been devoted at the identification of druggable vulne...
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| Format: | Article |
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MDPI AG
2019-02-01
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| Series: | Cells |
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| Online Access: | https://www.mdpi.com/2073-4409/8/2/150 |
| _version_ | 1797728510640390144 |
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| author | Sonia Coni Laura Di Magno Silvia Maria Serrao Yuta Kanamori Enzo Agostinelli Gianluca Canettieri |
| author_facet | Sonia Coni Laura Di Magno Silvia Maria Serrao Yuta Kanamori Enzo Agostinelli Gianluca Canettieri |
| author_sort | Sonia Coni |
| collection | DOAJ |
| description | Hedgehog (Hh) signaling is a critical developmental regulator and its aberrant activation, due to somatic or germline mutations of genes encoding pathway components, causes Basal Cell Carcinoma (BCC) and medulloblastoma (MB). A growing effort has been devoted at the identification of druggable vulnerabilities of the Hedgehog signaling, leading to the identification of various compounds with variable efficacy and/or safety. Emerging evidence shows that an aberrant polyamine metabolism is a hallmark of Hh-dependent tumors and that its pharmacological inhibition elicits relevant therapeutic effects in clinical or preclinical models of BCC and MB. We discuss here the current knowledge of polyamine metabolism, its role in cancer and the available targeting strategies. We review the literature about the connection between polyamines and the Hedgehog signaling, and the potential therapeutic benefit of targeting polyamine metabolism in two malignancies where Hh pathways play a well-established role: BCC and MB. |
| first_indexed | 2024-03-12T11:15:04Z |
| format | Article |
| id | doaj.art-c2fc575bd2644836bbaf319a1331744f |
| institution | Directory Open Access Journal |
| issn | 2073-4409 |
| language | English |
| last_indexed | 2024-03-12T11:15:04Z |
| publishDate | 2019-02-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cells |
| spelling | doaj.art-c2fc575bd2644836bbaf319a1331744f2023-09-02T02:15:30ZengMDPI AGCells2073-44092019-02-018215010.3390/cells8020150cells8020150Polyamine Metabolism as a Therapeutic Target in Hedgehog-Driven Basal Cell Carcinoma and MedulloblastomaSonia Coni0Laura Di Magno1Silvia Maria Serrao2Yuta Kanamori3Enzo Agostinelli4Gianluca Canettieri5Department of Molecular Medicine, Sapienza University, 00161 Rome, ItalyCenter for Life Nano Science@Sapienza, Istituto Italiano di Tecnologia, 00161 Rome, ItalyDepartment of Molecular Medicine, Sapienza University, 00161 Rome, ItalyDepartment of Biochemical Sciences ‘A. Rossi Fanelli’, Sapienza University, 00185 Rome, ItalyDepartment of Biochemical Sciences ‘A. Rossi Fanelli’, Sapienza University, 00185 Rome, ItalyDepartment of Molecular Medicine, Sapienza University, 00161 Rome, ItalyHedgehog (Hh) signaling is a critical developmental regulator and its aberrant activation, due to somatic or germline mutations of genes encoding pathway components, causes Basal Cell Carcinoma (BCC) and medulloblastoma (MB). A growing effort has been devoted at the identification of druggable vulnerabilities of the Hedgehog signaling, leading to the identification of various compounds with variable efficacy and/or safety. Emerging evidence shows that an aberrant polyamine metabolism is a hallmark of Hh-dependent tumors and that its pharmacological inhibition elicits relevant therapeutic effects in clinical or preclinical models of BCC and MB. We discuss here the current knowledge of polyamine metabolism, its role in cancer and the available targeting strategies. We review the literature about the connection between polyamines and the Hedgehog signaling, and the potential therapeutic benefit of targeting polyamine metabolism in two malignancies where Hh pathways play a well-established role: BCC and MB.https://www.mdpi.com/2073-4409/8/2/150Hedgehogpolyaminesmedulloblastomabasal cell carcinoma<span style="font-variant: small-caps">d</span>,<span style="font-variant: small-caps">l</span>-alpha-difluoromethylornithine |
| spellingShingle | Sonia Coni Laura Di Magno Silvia Maria Serrao Yuta Kanamori Enzo Agostinelli Gianluca Canettieri Polyamine Metabolism as a Therapeutic Target in Hedgehog-Driven Basal Cell Carcinoma and Medulloblastoma Cells Hedgehog polyamines medulloblastoma basal cell carcinoma <span style="font-variant: small-caps">d</span>,<span style="font-variant: small-caps">l</span>-alpha-difluoromethylornithine |
| title | Polyamine Metabolism as a Therapeutic Target in Hedgehog-Driven Basal Cell Carcinoma and Medulloblastoma |
| title_full | Polyamine Metabolism as a Therapeutic Target in Hedgehog-Driven Basal Cell Carcinoma and Medulloblastoma |
| title_fullStr | Polyamine Metabolism as a Therapeutic Target in Hedgehog-Driven Basal Cell Carcinoma and Medulloblastoma |
| title_full_unstemmed | Polyamine Metabolism as a Therapeutic Target in Hedgehog-Driven Basal Cell Carcinoma and Medulloblastoma |
| title_short | Polyamine Metabolism as a Therapeutic Target in Hedgehog-Driven Basal Cell Carcinoma and Medulloblastoma |
| title_sort | polyamine metabolism as a therapeutic target in hedgehog driven basal cell carcinoma and medulloblastoma |
| topic | Hedgehog polyamines medulloblastoma basal cell carcinoma <span style="font-variant: small-caps">d</span>,<span style="font-variant: small-caps">l</span>-alpha-difluoromethylornithine |
| url | https://www.mdpi.com/2073-4409/8/2/150 |
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