Morgagnian cataract resulting from a naturally occurring nonsense mutation elucidates a role of CPAMD8 in mammalian lens development.

Morgagnian cataract resulting from a naturally occurring nonsense mutation elucidates a role of CPAMD8 in mammalian lens development.

To investigate the genetic basis of hereditary lens opacities we analyzed 31 cases of bilateral congenital cataract in Red Holstein Friesian cattle. A genome-wide association study revealed a significant association on bovine chromosome 7 at positions 6,166,179 and 12,429,691. Whole genome re-sequen...

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Bibliographic Details
Main Authors: Anne K Hollmann, Insa Dammann, Wiebke M Wemheuer, Wilhelm E Wemheuer, Almuth Chilla, Andrea Tipold, Walter J Schulz-Schaeffer, Julia Beck, Ekkehard Schütz, Bertram Brenig
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2017-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC5500361?pdf=render

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http://europepmc.org/articles/PMC5500361?pdf=render

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