Effect of X-ray radiation on the pharmacokinetics of apatinib in vivo in rats

Purpose: The “radiotherapy-pharmacokinetic” (“RT-PK”) phenomenon refers to the fact that radiation can significantly alter the pharmacokinetic behavior of a drug. At present, it is not clear whether there is an “RT-PK” phenomenon that can affect apatinib during concurrent chemoradiotherapy. In this...

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Bibliographic Details
Main Authors: Shi-Qi Dong, Fan Yang, Dong-Xu Zhang, Ling-Mei Wang, Jian-Feng Liu, Ai-Jie Zhang, Hui-Rong Fan
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-09-01
Series:Frontiers in Pharmacology
Subjects:
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2022.943812/full