CHIPIN: ChIP-seq inter-sample normalization based on signal invariance across transcriptionally constant genes

CHIPIN: ChIP-seq inter-sample normalization based on signal invariance across transcriptionally constant genes

Abstract Background Multiple studies rely on ChIP-seq experiments to assess the effect of gene modulation and drug treatments on protein binding and chromatin structure. However, most methods commonly used for the normalization of ChIP-seq binding intensity signals across conditions, e.g., the norma...

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Bibliographic Details
Main Authors: Lélia Polit, Gwenneg Kerdivel, Sebastian Gregoricchio, Michela Esposito, Christel Guillouf, Valentina Boeva
Format: Article
Language:English
Published: BMC 2021-08-01
Series:BMC Bioinformatics
Subjects:
ChIP-seq
Open chromatin
Normalization
Density profiles
Gene expression
Algorithm
Online Access:https://doi.org/10.1186/s12859-021-04320-3

Internet

https://doi.org/10.1186/s12859-021-04320-3

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