Pharmacological Targeting of BMP6-SMAD Mediated Hepcidin Expression Does Not Improve the Outcome of Systemic Infections With Intra-Or Extracellular Gram-Negative Bacteria in Mice

Pharmacological Targeting of BMP6-SMAD Mediated Hepcidin Expression Does Not Improve the Outcome of Systemic Infections With Intra-Or Extracellular Gram-Negative Bacteria in Mice

IntroductionHepcidin is the systemic master regulator of iron metabolism as it degrades the cellular iron exporter ferroportin. In bacterial infections, hepcidin is upregulated to limit circulating iron for pathogens, thereby increasing iron retention in macrophages. This mechanism withholds iron fr...

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Bibliographic Details
Main Authors: Alexander Hoffmann, Lara Valente de Souza, Markus Seifert, Laura von Raffay, David Haschka, Philipp Grubwieser, Manuel Grander, Anna-Maria Mitterstiller, Manfred Nairz, Maura Poli, Günter Weiss
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-07-01
Series:Frontiers in Cellular and Infection Microbiology
Subjects:
hepcidin inhibitor
infection
Gram-negative bacteria
over-sulfated heparins
LDN-193189
Salmonella
Online Access:https://www.frontiersin.org/articles/10.3389/fcimb.2021.705087/full

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https://www.frontiersin.org/articles/10.3389/fcimb.2021.705087/full

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