Proline is increased in allergic asthma and promotes airway remodeling

Proline is increased in allergic asthma and promotes airway remodeling

Proline and its synthesis enzyme pyrroline-5-carboxylate reductase 1 (PYCR1) are implicated in epithelial-mesenchymal transition (EMT), yet how proline and PYCR1 function in allergic asthmatic airway remodeling via EMT has not yet been addressed to our knowledge. In the present study, increased leve...

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Bibliographic Details
Main Authors: Tingting Xu, Zhenzhen Wu, Qi Yuan, Xijie Zhang, Yanan Liu, Chaojie Wu, Meijuan Song, Jingjing Wu, Jingxian Jiang, Zhengxia Wang, Zhongqi Chen, Mingshun Zhang, Mao Huang, Ningfei Ji
Format: Article
Language:English
Published: American Society for Clinical investigation 2023-08-01
Series:JCI Insight
Subjects:
Metabolism
Pulmonology
Online Access:https://doi.org/10.1172/jci.insight.167395

Internet

https://doi.org/10.1172/jci.insight.167395

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