Mapping the functional impact of non-coding regulatory elements in primary T cells through single-cell CRISPR screens

Mapping the functional impact of non-coding regulatory elements in primary T cells through single-cell CRISPR screens

Abstract Background Drug targets with genetic evidence are expected to increase clinical success by at least twofold. Yet, translating disease-associated genetic variants into functional knowledge remains a fundamental challenge of drug discovery. A key issue is that the vast majority of complex dis...

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Bibliographic Details
Main Authors: Celia Alda-Catalinas, Ximena Ibarra-Soria, Christina Flouri, Jorge Esparza Gordillo, Diana Cousminer, Anna Hutchinson, Bin Sun, William Pembroke, Sebastian Ullrich, Adam Krejci, Adrian Cortes, Alison Acevedo, Sunir Malla, Carl Fishwick, Gerard Drewes, Radu Rapiteanu
Format: Article
Language:English
Published: BMC 2024-02-01
Series:Genome Biology
Subjects:
Enhancer
Regulatory element
GWAS
Variant to function
crisprQTL
CRISPR
Online Access:https://doi.org/10.1186/s13059-024-03176-z

Internet

https://doi.org/10.1186/s13059-024-03176-z

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