CRIPTO antagonist ALK4L75A-Fc inhibits breast cancer cell plasticity and adaptation to stress

CRIPTO antagonist ALK4L75A-Fc inhibits breast cancer cell plasticity and adaptation to stress

Abstract Background CRIPTO is a multi-functional signaling protein that promotes stemness and oncogenesis. We previously developed a CRIPTO antagonist, ALK4L75A-Fc, and showed that it causes loss of the stem cell phenotype in normal mammary epithelia suggesting it may similarly inhibit CRIPTO-depend...

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Bibliographic Details
Main Authors: Ozlen Balcioglu, Richard E. Heinz, David W. Freeman, Brooke L. Gates, Berhane M. Hagos, Evan Booker, Elnaz Mirzaei Mehrabad, Hyrum T. Diesen, Kishan Bhakta, Supraja Ranganathan, Masami Kachi, Mathias Leblanc, Peter C. Gray, Benjamin T. Spike
Format: Article
Language:English
Published: BMC 2020-11-01
Series:Breast Cancer Research
Subjects:
Breast cancer
Plasticity
CRIPTO
Stress adaptation
Cancer stem cells
Online Access:http://link.springer.com/article/10.1186/s13058-020-01361-z

Internet

http://link.springer.com/article/10.1186/s13058-020-01361-z

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