Cholesteryl hemiazelate identified in CVD patients causes in vitro and in vivo inflammation

Cholesteryl hemiazelate identified in CVD patients causes in vitro and in vivo inflammation

Oxidation of PUFAs in LDLs trapped in the arterial intima plays a critical role in atherosclerosis. Though there have been many studies on the atherogenicity of oxidized derivatives of PUFA-esters of cholesterol, the effects of cholesteryl hemiesters (ChEs), the oxidation end products of these ester...

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Bibliographic Details
Main Authors: Neuza Domingues, Joana Gaifem, Rune Matthiesen, Diana P. Saraiva, Luís Bento, André R.A. Marques, Maria I.L. Soares, Julio Sampaio, Christian Klose, Michal A. Surma, Manuel S. Almeida, Gustavo Rodrigues, Pedro Araújo Gonçalves, Jorge Ferreira, Ryan Gouveia e Melo, Luís Mendes Pedro, Kai Simons, Teresa M.V.D. Pinho e Melo, M. Guadalupe Cabral, Antonio Jacinto, Ricardo Silvestre, Winchil Vaz, Otília V. Vieira
Format: Article
Language:English
Published: Elsevier 2023-09-01
Series:Journal of Lipid Research
Subjects:
cholesteryl hemiesters
cholesteryl hemiazelates
lipidomics
innate inflammatory responses
atherosclerosis
Online Access:http://www.sciencedirect.com/science/article/pii/S0022227523000925

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http://www.sciencedirect.com/science/article/pii/S0022227523000925

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