Establishment and characterization of an hACE2/hTMPRSS2 knock-in mouse model to study SARS-CoV-2

Establishment and characterization of an hACE2/hTMPRSS2 knock-in mouse model to study SARS-CoV-2

Despite a substantial body of research, we lack fundamental understanding of the pathophysiology of COVID-19 caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) including pulmonary and cardiovascular outcomes, in part due to limitations of murine models. Most models use transgenic...

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Bibliographic Details
Main Authors: Hongwei Liu, Terza Brostoff, Ana Ramirez, Talia Wong, Douglas J. Rowland, Mollie Heffner, Arturo Flores, Brandon Willis, Jeffrey J. Evans, Louise Lanoue, K. C. Kent Lloyd, Lark L. Coffey
Format: Article
Language:English
Published: Frontiers Media S.A. 2024-07-01
Series:Frontiers in Immunology
Subjects:
SARS-CoV-2
mouse ACE2
mouse TMPRSS2
knock-in mouse
COVID-19
virus
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2024.1428711/full

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https://www.frontiersin.org/articles/10.3389/fimmu.2024.1428711/full

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