Heterozygous HbAC but not HbAS is associated with higher newborn birthweight among women with pregnancy-associated malaria
Abstract Pregnancy-associated malaria (PAM) is associated with poor pregnancy outcomes. Hemoglobin S (HbS) and hemoglobin C (HbC) mutations are frequently encountered in malaria-endemic areas of Africa, where they protect children from severe and uncomplicated Plasmodium falciparum malaria. However,...
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| Format: | Article |
| Language: | English |
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Nature Portfolio
2017-05-01
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| Series: | Scientific Reports |
| Online Access: | https://doi.org/10.1038/s41598-017-01495-9 |
| _version_ | 1818995187988299776 |
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| author | Marilou Tétard Jacqueline Milet Sébastien Dechavanne Nadine Fievet Dominique Dorin-Semblat Jacques Elion Rick M. Fairhurst Philippe Deloron Nicaise Tuikue-Ndam Benoît Gamain |
| author_facet | Marilou Tétard Jacqueline Milet Sébastien Dechavanne Nadine Fievet Dominique Dorin-Semblat Jacques Elion Rick M. Fairhurst Philippe Deloron Nicaise Tuikue-Ndam Benoît Gamain |
| author_sort | Marilou Tétard |
| collection | DOAJ |
| description | Abstract Pregnancy-associated malaria (PAM) is associated with poor pregnancy outcomes. Hemoglobin S (HbS) and hemoglobin C (HbC) mutations are frequently encountered in malaria-endemic areas of Africa, where they protect children from severe and uncomplicated Plasmodium falciparum malaria. However, scant epidemiological data exist on the impact of these Hb variants on PAM. A prospective cohort of 635 Beninese pregnant women was recruited before 24 weeks of gestational age and followed until the end of pregnancy. HbAA, HbAC, and HbAS genotypes were determined and tested for association with pregnancy outcomes and PAM indicators using linear and logistic multivariate models. Newborns from HbAC mothers had higher birthweights than those from HbAA mothers among women infected at any time during pregnancy (mean difference 182.9 g, p = 0.08), or during the first half of pregnancy (654.3 g, p = 0.0006). No such birthweight differences were observed between newborns from HbAS and HbAA mothers. HbAC and HbAS were not associated with other pregnancy outcomes or PAM indicators. In conclusion, HbAC but not HbAS is associated with an improved birth outcome in pregnant women with documented PAM. Higher-birthweight newborns from HbAC mothers may have a survival advantage that contributes to the natural selection of HbC in malaria-endemic areas. |
| first_indexed | 2024-12-20T21:09:52Z |
| format | Article |
| id | doaj.art-c31a1bd9e7014fffac41459587679ee6 |
| institution | Directory Open Access Journal |
| issn | 2045-2322 |
| language | English |
| last_indexed | 2024-12-20T21:09:52Z |
| publishDate | 2017-05-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Scientific Reports |
| spelling | doaj.art-c31a1bd9e7014fffac41459587679ee62022-12-21T19:26:33ZengNature PortfolioScientific Reports2045-23222017-05-01711810.1038/s41598-017-01495-9Heterozygous HbAC but not HbAS is associated with higher newborn birthweight among women with pregnancy-associated malariaMarilou Tétard0Jacqueline Milet1Sébastien Dechavanne2Nadine Fievet3Dominique Dorin-Semblat4Jacques Elion5Rick M. Fairhurst6Philippe Deloron7Nicaise Tuikue-Ndam8Benoît Gamain9Université Sorbonne Paris Cité, Université Paris Diderot, Inserm, INTS, Unité Biologie Intégrée du Globule Rouge, Laboratoire d’Excellence GR-ExInstitut de Recherche pour le Développement, UMR 216, Mère et Enfant face aux Infections TropicalesUniversité Sorbonne Paris Cité, Université Paris Diderot, Inserm, INTS, Unité Biologie Intégrée du Globule Rouge, Laboratoire d’Excellence GR-ExInstitut de Recherche pour le Développement, UMR 216, Mère et Enfant face aux Infections TropicalesUniversité Sorbonne Paris Cité, Université Paris Diderot, Inserm, INTS, Unité Biologie Intégrée du Globule Rouge, Laboratoire d’Excellence GR-ExUniversité Sorbonne Paris Cité, Université Paris Diderot, Inserm, INTS, Unité Biologie Intégrée du Globule Rouge, Laboratoire d’Excellence GR-ExLaboratory of Malaria and Vector Research, National Institute of Allergy and Infectious Diseases, National Institutes of HealthInstitut de Recherche pour le Développement, UMR 216, Mère et Enfant face aux Infections TropicalesInstitut de Recherche pour le Développement, UMR 216, Mère et Enfant face aux Infections TropicalesUniversité Sorbonne Paris Cité, Université Paris Diderot, Inserm, INTS, Unité Biologie Intégrée du Globule Rouge, Laboratoire d’Excellence GR-ExAbstract Pregnancy-associated malaria (PAM) is associated with poor pregnancy outcomes. Hemoglobin S (HbS) and hemoglobin C (HbC) mutations are frequently encountered in malaria-endemic areas of Africa, where they protect children from severe and uncomplicated Plasmodium falciparum malaria. However, scant epidemiological data exist on the impact of these Hb variants on PAM. A prospective cohort of 635 Beninese pregnant women was recruited before 24 weeks of gestational age and followed until the end of pregnancy. HbAA, HbAC, and HbAS genotypes were determined and tested for association with pregnancy outcomes and PAM indicators using linear and logistic multivariate models. Newborns from HbAC mothers had higher birthweights than those from HbAA mothers among women infected at any time during pregnancy (mean difference 182.9 g, p = 0.08), or during the first half of pregnancy (654.3 g, p = 0.0006). No such birthweight differences were observed between newborns from HbAS and HbAA mothers. HbAC and HbAS were not associated with other pregnancy outcomes or PAM indicators. In conclusion, HbAC but not HbAS is associated with an improved birth outcome in pregnant women with documented PAM. Higher-birthweight newborns from HbAC mothers may have a survival advantage that contributes to the natural selection of HbC in malaria-endemic areas.https://doi.org/10.1038/s41598-017-01495-9 |
| spellingShingle | Marilou Tétard Jacqueline Milet Sébastien Dechavanne Nadine Fievet Dominique Dorin-Semblat Jacques Elion Rick M. Fairhurst Philippe Deloron Nicaise Tuikue-Ndam Benoît Gamain Heterozygous HbAC but not HbAS is associated with higher newborn birthweight among women with pregnancy-associated malaria Scientific Reports |
| title | Heterozygous HbAC but not HbAS is associated with higher newborn birthweight among women with pregnancy-associated malaria |
| title_full | Heterozygous HbAC but not HbAS is associated with higher newborn birthweight among women with pregnancy-associated malaria |
| title_fullStr | Heterozygous HbAC but not HbAS is associated with higher newborn birthweight among women with pregnancy-associated malaria |
| title_full_unstemmed | Heterozygous HbAC but not HbAS is associated with higher newborn birthweight among women with pregnancy-associated malaria |
| title_short | Heterozygous HbAC but not HbAS is associated with higher newborn birthweight among women with pregnancy-associated malaria |
| title_sort | heterozygous hbac but not hbas is associated with higher newborn birthweight among women with pregnancy associated malaria |
| url | https://doi.org/10.1038/s41598-017-01495-9 |
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