Cannabimimetic <i>N</i>-Stearoylethanolamine as “Double-Edged Sword” in Anticancer Chemotherapy: Proapoptotic Effect on Tumor Cells and Suppression of Tumor Growth versus Its Bio-Protective Actions in Complex with Polymeric Carrier on General Toxicity of Doxorubicin In Vivo

Cannabimimetic <i>N</i>-Stearoylethanolamine as “Double-Edged Sword” in Anticancer Chemotherapy: Proapoptotic Effect on Tumor Cells and Suppression of Tumor Growth versus Its Bio-Protective Actions in Complex with Polymeric Carrier on General Toxicity of Doxorubicin In Vivo

This study reports a dose-dependent pro-apoptotic action of synthetic cannabimimetic <i>N</i>-stearoylethanolamine (NSE) on diverse cancer cell lines, including multidrug-resistant models. No antioxidant or cytoprotective effects of NSE were found when it was applied together with doxoru...

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Bibliographic Details
Main Authors: Rostyslav Panchuk, Nadiya Skorokhyd, Vira Chumak, Lilya Lehka, Halyna Kosiakova, Tetyana Horid’ko, Iehor Hudz, Nadiya Hula, Anna Riabtseva, Nataliya Mitina, Alexander Zaichenko, Petra Heffeter, Walter Berger, Rostyslav Stoika
Format: Article
Language:English
Published: MDPI AG 2023-03-01
Series:Pharmaceutics
Subjects:
doxorubicin
<i>N</i>-stearoylethanolamine
polymeric carriers
tumor cells
drug resistance
apoptosis
Online Access:https://www.mdpi.com/1999-4923/15/3/835

Internet

https://www.mdpi.com/1999-4923/15/3/835

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