Triple Combination of Ascorbate, Menadione and the Inhibition of Peroxiredoxin-1 Produces Synergistic Cytotoxic Effects in Triple-Negative Breast Cancer Cells

Triple Combination of Ascorbate, Menadione and the Inhibition of Peroxiredoxin-1 Produces Synergistic Cytotoxic Effects in Triple-Negative Breast Cancer Cells

Triple-negative breast cancer (TNBC) is an aggressive form of mammary malignancy currently without satisfactory systemic treatment options. Agents generating reactive oxygen species (ROS), such as ascorbate (Asc) and menadione (Men), especially applied in combination, have been proposed as an altern...

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Bibliographic Details
Main Authors: Malgorzata Bajor, Agnieszka Graczyk-Jarzynka, Katsiaryna Marhelava, Malgorzata Kurkowiak, Arman Rahman, Claudia Aura, Niamh Russell, Agata O. Zych, Malgorzata Firczuk, Magdalena Winiarska, William M. Gallagher, Radoslaw Zagozdzon
Format: Article
Language:English
Published: MDPI AG 2020-04-01
Series:Antioxidants
Subjects:
triple therapeutic combination
antioxidant enzyme
prooxidant agents
augmented prooxidant therapy
triple-negative breast cancer
Online Access:https://www.mdpi.com/2076-3921/9/4/320

Internet

https://www.mdpi.com/2076-3921/9/4/320

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