Cyclooxygenase-Inhibiting Platinum(IV) Prodrugs with Potent Anticancer Activity

Cyclooxygenase-Inhibiting Platinum(IV) Prodrugs with Potent Anticancer Activity

Platinum(IV) prodrugs of the [Pt(P<sub>L</sub>)(A<sub>L</sub>)(COXi)(OH)]<sup>2+</sup> type scaffold (where P<sub>L</sub> is 1,10-phenanthroline or 5,6-dimethyl-1,10-phenanthroline, A<sub>L</sub> is 1<i>S</i>,2<i>S</i&g...

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Bibliographic Details
Main Authors: Aleen Khoury, Jennette A. Sakoff, Jayne Gilbert, Kieran F. Scott, Shawan Karan, Christopher P. Gordon, Janice R. Aldrich-Wright
Format: Article
Language:English
Published: MDPI AG 2022-04-01
Series:Pharmaceutics
Subjects:
platinum(IV)
prodrugs
cancer
cyclooxygenase
56MESS
cytotoxicity
Online Access:https://www.mdpi.com/1999-4923/14/4/787

Internet

https://www.mdpi.com/1999-4923/14/4/787

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