Sphingosine kinase 1/S1P receptor signaling axis is essential for cellular uptake of Neisseria meningitidis in brain endothelial cells.

Sphingosine kinase 1/S1P receptor signaling axis is essential for cellular uptake of Neisseria meningitidis in brain endothelial cells.

Invasion of brain endothelial cells (BECs) is central to the pathogenicity of Neisseria meningitidis infection. Here, we established a key role for the bioactive sphingolipid sphingosine-1-phosphate (S1P) and S1P receptor (S1PR) 2 in the uptake process. Quantitative sphingolipidome analyses of BECs...

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Bibliographic Details
Main Authors: Ingo Fohmann, Alina Weinmann, Fabian Schumacher, Simon Peters, Agata Prell, Cynthia Weigel, Sarah Spiegel, Burkhard Kleuser, Alexandra Schubert-Unkmeir
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2023-11-01
Series:PLoS Pathogens
Online Access:https://journals.plos.org/plospathogens/article/file?id=10.1371/journal.ppat.1011842&type=printable

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https://journals.plos.org/plospathogens/article/file?id=10.1371/journal.ppat.1011842&type=printable

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