Development of high-throughput lacrimal gland organoid platforms for drug discovery in dry eye disease

Development of high-throughput lacrimal gland organoid platforms for drug discovery in dry eye disease

Dysfunction and damage of the lacrimal gland (LG) results in ocular discomfort and dry eye disease (DED). Current therapies for DED do not fully replenish the necessary lubrication to rescue optimal vision. New drug discovery for DED has been limited perhaps because in vitro models cannot mimic the...

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Bibliographic Details
Main Authors: Teerapat Rodboon, Supansa Yodmuang, Risa Chaisuparat, Joao N. Ferreira
Format: Article
Language:English
Published: Elsevier 2022-04-01
Series:SLAS Discovery
Subjects:
Dry eye disease
Xerophthalmia
Lacrimal gland
Organoids
Bioprinting
Drug discovery
Online Access:http://www.sciencedirect.com/science/article/pii/S2472555221000174

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http://www.sciencedirect.com/science/article/pii/S2472555221000174

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