ATP protects anti-PD-1/radiation-induced cardiac dysfunction by inhibiting anti-PD-1 exacerbated cardiomyocyte apoptosis, and improving autophagic flux

ATP protects anti-PD-1/radiation-induced cardiac dysfunction by inhibiting anti-PD-1 exacerbated cardiomyocyte apoptosis, and improving autophagic flux

The synergy between radiotherapy and immunotherapy in treating thoracic cancers presents a potent therapeutic advantage, yet it also carries potential risks. The extent and nature of cumulative cardiac toxicity remain uncertain, prompting the need to discern its mechanisms and devise effective mitig...

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Bibliographic Details
Main Authors: Jing Wang, Jing Zhao, Zhijun Meng, Rui Guo, Ruihong Yang, Caihong Liu, Jia Gao, Yaoli Xie, Xiangying Jiao, Heping Fang, Jianli Zhao, Yajing Wang, Jimin Cao
Format: Article
Language:English
Published: Elsevier 2023-10-01
Series:Heliyon
Subjects:
Radiation
Anti-PD-1 antibody
Cardiotoxicity
Autophagy
Apoptosis
Online Access:http://www.sciencedirect.com/science/article/pii/S2405844023078684

Internet

http://www.sciencedirect.com/science/article/pii/S2405844023078684

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