Natural product fragment combination to performance-diverse pseudo-natural products

Natural products inspire the development of pseudo-natural products through combinations of fragments of compound classes that are chemically and biologically distinct. Here, the authors report a library of 244 pseudo-natural products, evaluate them in the cell painting essays and identify the pheno...

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Bibliographic Details
Main Authors: Michael Grigalunas, Annina Burhop, Sarah Zinken, Axel Pahl, José-Manuel Gally, Niklas Wild, Yannik Mantel, Sonja Sievers, Daniel J. Foley, Rebecca Scheel, Carsten Strohmann, Andrey P. Antonchick, Herbert Waldmann
Format: Article
Language:English
Published: Nature Portfolio 2021-03-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-021-22174-4