Inhibition of Human Urokinase-Type Plasminogen Activator (uPA) Enzyme Activity and Receptor Binding by DNA Aptamers as Potential Therapeutics through Binding to the Different Forms of uPA

Inhibition of Human Urokinase-Type Plasminogen Activator (uPA) Enzyme Activity and Receptor Binding by DNA Aptamers as Potential Therapeutics through Binding to the Different Forms of uPA

Urokinase-type plasminogen activator is widely discussed as a marker for cancer prognosis and diagnosis and as a target for cancer therapies. Together with its receptor, uPA plays an important role in tumorigenesis, tumor progression and metastasis. In the present study, systematic evolution of liga...

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Bibliographic Details
Main Authors: Nico Dreymann, Julia Wuensche, Wiebke Sabrowski, Anja Moeller, Denise Czepluch, Dana Vu Van, Susanne Fuessel, Marcus M. Menger
Format: Article
Language:English
Published: MDPI AG 2022-04-01
Series:International Journal of Molecular Sciences
Subjects:
biomarker
cancer
cancer therapy
DNA aptamer
microscale thermophoresis (MST)
SELEX
Online Access:https://www.mdpi.com/1422-0067/23/9/4890

Internet

https://www.mdpi.com/1422-0067/23/9/4890

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