Formononetin Upregulates Nrf2/HO-1 Signaling and Prevents Oxidative Stress, Inflammation, and Kidney Injury in Methotrexate-Induced Rats

Formononetin Upregulates Nrf2/HO-1 Signaling and Prevents Oxidative Stress, Inflammation, and Kidney Injury in Methotrexate-Induced Rats

Acute kidney injury (AKI) is a serious complication of methotrexate (MTX). This study explored the protective effect of the isoflavone formononetin (FN) against MTX nephrotoxicity with an emphasis on oxidative stress, inflammation, and nuclear factor (erythroid-derived 2)-like 2/heme oxygenase 1 (Nr...

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Bibliographic Details
Main Authors: Saleem H. Aladaileh, Omnia E. Hussein, Mohammad H. Abukhalil, Sultan A. M. Saghir, May Bin-Jumah, Manal A. Alfwuaires, Mousa O. Germoush, Amer A. Almaiman, Ayman M. Mahmoud
Format: Article
Language:English
Published: MDPI AG 2019-09-01
Series:Antioxidants
Subjects:
formononetin
methotrexate
ros
nrf2
nephrotoxicity
Online Access:https://www.mdpi.com/2076-3921/8/10/430

Internet

https://www.mdpi.com/2076-3921/8/10/430

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